The shocks hit at 1:24 am around 46 kilometers (28.5 miles) southwest of the city of Khost, which lies close to the country’s border with Pakistan, according to the United States Geological Survey (USGS).
The quake registered at a depth of 10 kilometers (6.2 miles), according to USGS, which designated it at yellow alert level – indicating a relatively localized impact.
The death toll stands at more than 900 and at least 600 people have been injured, Deputy Minister for the State Ministry for Disaster Management Sharafuddin Muslem told a news conference Wednesday.
Most of the deaths were in Paktika province, in the districts of Giyan, Nika, Barmal and Zirok, according to the ministry.
In neighboring Khost province, 25 people were killed and several others were injured, and five people were killed in Nangarhar province, the disaster management authority said.
Photos from Paktika province, just south of Khost province, show houses turned to rubble with only one wall or two still standing amid the rubble, and broken roof beams.
Najibullah Sadid, an Afghan water resources management expert, said the earthquake had coincided with heavy monsoon rains in the region – making traditional houses, many made of mud and other natural materials, particularly vulnerable to damage.
“The timing of the earthquake (in the) dark of night … and the shallow depth of 10 kilometers of its epicenter led to higher casualties,” he added.
A team of medics and seven helicopters have been sent to the area to transport injured people to nearby hospitals, Afghanistan’s Ministry of Defense said in a tweet on Wednesday.
The situation has crippled an economy already heavily dependent on aid. Following the chaotic US withdrawal from Afghanistan last year, its economy has gone into freefall with the World Bank forecasting in April that a “combination of declining incomes and rising prices has driven a severe deterioration in household living standards.”
The Taliban held an emergency meeting on Wednesday to organize providing transportation to the injured and material aid to the victims and their families, Taliban spokesman Zabiullah Mujahid said.
Prime Minister Mohammad Hassan Akhund called the meeting at the country’s Presidential Palace to instruct all relevant agencies to send emergency relief teams to the affected area, Mujahid said in a tweet.
“Measures were also taken to provide cash assistance and treatment,” Mujahid said and added that agencies were “instructed to use air and land transport for the delivery of food, clothing, medicine and other necessities and for the transportation of the wounded.”
In a tweet on Wednesday, the World Health Organization said its teams were on the ground for emergency response, including providing medicine, trauma services and conducting needs assessments.
Pakistan’s Prime Minister Shehbaz Sharif extended his condolences and an offer of support in a tweet on Wednesday. “Deeply grieved to learn about the earthquake in Afghanistan, resulting in the loss of innocent lives,” he wrote. “People in Pakistan share the grief and sorrow of their Afghan brethren. Relevant authorities are working to support Afghanistan in this time of need.”
India expressed “sympathy and condolences to the victims and their families,” according to a tweet by the spokesperson of the Indian Ministry of External Affairs on Wednesday.
Pope Francis said he was praying “for those who have lost their lives and for their families,” during his weekly audience on Wednesday. “I hope aid can be sent there to help all the suffering of the dear people of Afghanistan.”
Afghanistan has a long history of earthquakes, many of which happen in the mountainous Hindu Kush region that borders with Pakistan.
CNN’s Hada Messia contributed to this report.